TI: The regulation of platelet aggregation in vitro by interleukin-1beta and tumor necrosis factor-alpha: changes in pregnancy and in pre-eclampsia. Регулирование скопления тромбоцита in itro интерлейкином-1beta и альфой фактора некроза опухоли: изменения(замены) в беременности и в преэклампсии.
AU: Bar-J; Zosmer-A; Hod-M; Elder-MG; Sullivan-MH
AD: Department of Obstetrics and Gynaecology, Rabin Medical Centre, Petah Tiqva and Sackler Faculty of Medicine, Tel Aviv University, Israel.
SO: Thromb-Haemost. 1997 Oct; 78(4): 1255-61
CP: GERMANY
AB: Platelet activation occurs in early pregnancy in women at risk of developing pre-eclampsia. Cytokines have been implicated in the pathogenesis of pre-eclampsia, so we determined the effects of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) on the in vitro aggregation of human platelets. IL-1beta increased aggregation of platelets from non-pregnant and pre-eclamptic women, and inhibited the aggregation of platelets from normal pregnant women. This latter effect was linked to a diminished P-selectin expression on ADP-stimulated whole blood platelets in normal pregnant women (p = 0.011). Platelet aggregation in response to ADP was found to be inhibited after preincubation with TNF-alpha in non-pregnant (38%, p = 0.01) and in normal pregnant women (54%, p = 0.001) and not affected in pre-eclamptic women. The inhibitory effects of TNF-alpha were mediated through the P75 receptor for TNF-alpha.
: Активация Тромбоцита встречается в ранней беременности в женщинах в опасности развивающейся преэклампсии. Цитокины были вовлечены в патогенезе преэклампсии, так что мы определили эффекты интерлейкина-1beta (IL-1beta) и альфы фактора некроза опухоли (tnf - АЛЬФА) на in itro скоплении человеческих тромбоцитов. IL-1beta увеличенное скопление тромбоцитов от небеременных и пред--eclamptic женщин, и ингибированный скопление тромбоцитов от нормальных беременных женщин. Этот последний эффект был связан с уменьшенным P - экспрессия Селектина на СТИМУЛИРУЕМЫХ АВТОМАТИЧЕСКОЙ ОБРАБОТКОЙ целых тромбоцитах крови в нормальных беременных женщинах (p = 0.011). Скопление Тромбоцита в реакции на АВТОМАТИЧЕСКУЮ ОБРАБОТКУ было найдено, чтобы быть ингибированным после преинкубации с tnf - АЛЬФА в небеременном (38 %, p = 0.01) и в нормальных беременных женщинах (54 %, p = 0.001) и не поврежденный в пред--eclamptic женщинах. Подавляющие эффекты tnf - АЛЬФА были установлены через P75 рецептор для tnf - АЛЬФА.
TI: A cross-sectional study of platelet volume in healthy normotensive women with bilateral uterine artery notches.
: Взаимно-частное(-секционное) изучение объема(издания) тромбоцита в здоровых normotensive женщинах с двусторонними утробными вырезками артерии.
AU: Lees-CC; Brown-AS; Harrington-KF; Beacon-HJ; Martin-JF; Campbell-S
AD: Department of Obstetrics and Gynaecology, St. George's Hospital Medical School, London, UK.
SO: Ultrasound-Obstet-Gynecol. 1997 Oct; 10(4): 277-81
CP: ENGLAND
AB: High uterine artery resistance characterized by bilateral notches seen on Doppler ultrasound in the second half of pregnancy is associated with an increased risk of adverse outcome related to pre-eclampsia and intrauterine growth retardation. We sought to establish whether there was a difference in platelet volume in healthy, normotensive women with high-resistance uterine artery Doppler findings compared to those with normal uterine artery Doppler findings. Forty-seven women were allocated prospectively into 'bilateral notch' and 'no notch' groups at color Doppler imaging of the uterine arteries carried out at a mean of 26 weeks' gestation. The difference in platelet volume between the two groups and the relationship of adverse outcome with raised platelet volume and high-resistance uterine artery Doppler findings was investigated. Twenty-three women had no evidence of uterine artery notches and 24 had bilateral uterine artery notches. Platelet volume in the women with bilateral notches was greater than in those with no notches (8.28 fl vs. 7.46 fl; p = 0.01). However, unlike high-resistance uterine artery Doppler findings, increased platelet volume was not associated with adverse outcome. Uterine artery Doppler flow abnormalities have not previously been studied in combination with hematological or biochemical markers. Our findings show, for the first time, that women with bilateral uterine artery notches have an increased platelet volume compared to those with normal uterine artery Doppler findings many weeks before clinical signs of pre-eclampsia or fetal growth retardation are evident. Women with abnormal uterine artery flow at this gestation may have other cardiovascular and hematological differences compared to those with normal flow.
Уважаемый посетитель!
Чтобы распечатать файл, скачайте его (в формате Word).
Ссылка на скачивание - внизу страницы.