AU: Kaibara-M; Mitsuhashi-Y; Watanabe-T; Tamiaki-F; Nishihira-M; Sadatsuki-M; Aisaka-K
AD: Department of Obstetrics and Gynecology, Teikyo University School of Medicine, Japan.
SO: Am-J-Obstet-Gynecol. 1999 Feb; 180(2 Pt 1): 402-5
CP: UNITED-STATES
AB: OBJECTIVE: The objective of this study was to determine the cellular effects of whole blood, especially of red blood cells, on the hypercoagulability of blood from patients with preeclampsia. STUDY DESIGN: The time elapsed between mixing and the onset of coagulation was measured by means of a highly sensitive rheometer for whole blood, platelet-rich plasma (in which red blood cells had been removed from whole blood), and platelet-free plasma from 3 groups of subjects: 25 nonpregnant women, 25 women with normal pregnancies, and 10 patients with preeclampsia. RESULTS: Time to coagulation for whole blood from patients with preeclampsia was significantly shorter than that for whole blood from women with normal pregnancies. However, there was no significant difference in time to coagulation for platelet-rich plasma between women with preeclampsia and those with normal pregnancies. CONCLUSION: Hypercoagulability of blood in preeclampsia appears to be strongly related to red blood cell alterations. : Цель этого изучения состояла в том, чтобы определить клеточные эффекты целой крови, особенно эритроцитов, на гиперкоагуляции крови от пациентов с преэклампсией. ПРОЕКТ ИЗУЧЕНИЯ: время, законченное между смешиванием и началом коагуляции было измерено посредством высоко чувствительного вискозиметра для целой крови, богатая тромбоцитом плазма (в котором эритроциты были удалены от целой крови), и плазмы без тромбоцита от 3 групп субъектов: 25 небеременных женщин, 25 женщин с нормальными беременностями, и 10 пациентами с преэклампсией. РЕЗУЛЬТАТЫ: Время к коагуляции для целой крови от пациентов с преэклампсией было значительно короче чем это для целой крови от женщин с нормальными беременностями. Однако, не было никакого значительного различия вовремя к коагуляции для богатой тромбоцитом плазмы между женщинами с преэклампсией и теми с нормальными беременностями. ЗАКЛЮЧЕНИЕ: Гиперкоагуляция крови в преэклампсии, кажется, быть связана с альтерациями эритроцита.
TI: Comparison of the differential distribution of leukocytes in preeclampsia versus uncomplicated pregnancy.
Сравнение отличительного распределения лейкоцитов в преэклампсии против несложной беременности.
AU: Lurie-S; Frenkel-E; Tuvbin-Y
AD: Department of Obstetrics and Gynecology, Assaf-Harofeh Medical Center, Zerifin, Israel.
SO: Gynecol-Obstet-Invest. 1998; 45(4): 229-31
CP: SWITZERLAND
AB: OBJECTIVE: To describe leukocyte count and differential distribution in preeclampsia and uncomplicated pregnancy. STUDY DESIGN: Blood samples were obtained from 46 consecutive preeclamptic patients and 46 controls with uncomplicated pregnancy. Thirty met the criteria for mild preeclampsia and 16 for severe. The blood was tested within 1 h of venepuncture. An aliquot of the blood was tested in the Cell-Dyn 2000 for complete blood cell count. MAIN RESULTS: The absolute neutrophil count was significantly elevated in preeclamptic patients as compared with that of controls with uncomplicated pregnancy (9,410.1+/-3,066.9 vs. 7,498.6+/-2,354.0 x 10(6)/l, p < 0.05). In neutrophils, the elevation was more prominent in severe preeclamptic patients as compared with mild preeclamptic patients (10,658.8+/-3520.4 vs. 8,694.4+/-2,561.9 x 10(6)/l, p < 0.05). The absolute lymphocyte and eosinophil counts declined in patients with preeclampsia as compared with uncomplicated pregnancy, whereas monocyte and basophil counts did not differ. CONCLUSION: Our results suggest that preeclampsia is associated with an increase in the absolute neutrophil count.
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