AB: Preeclampsia (PE) and eclampsia (E) are potentially life-threatening conditions that can occur during human pregnancy. Generally considered to be different degrees of severity of the same disease process, the PE/E syndrome is thought to be predominantly genetic in origin, although its exact etiology and genetics are not fully understood. Here we report results of a genomewide linkage search for the gene(s) responsible for susceptibility to PE/E, using 15 informative pedigrees and 90 polymorphic DNA markers from all autosomes. Because of uncertainties concerning inheritance and diagnosis, four different models that assume maternal gene expression have been used to carry out LOD-score analysis. The region between D4S450 and D4S610 (2.8 cM) on the long arm of chromosome 4 was identified as a strong candidate region for a PE/E-susceptibility locus. The maximum multipoint LOD score within this interval was 2.9. Analysis of markers in the region around D4S450 and D4S610 by the affected-pedigree-member method also supported the possibility of a susceptibility locus in this region. However, to verify or exclude definitively linkage to this region, other groups of PE/E pedigrees will be required.
: Преэклампсия (pe) и эклампсия (E) - потенциально условия(состояния) угрозы жизни, которые могут встречаться в течение человеческой беременности. Вообще рассматриваемый, чтобы быть различными степенями(градусами) серьезности того же самого процесса болезни, pe/E синдром, как думают, является преобладающе генетическим в происхождении, хотя его точная этиология и генетика полностью не поняты. Здесь мы сообщаем, что результаты genomewide связи ищут ген (ы), ответственный за восприимчивость к pe/E, используя 15 информативных родословных и 90 polymorphic маркеры ДНК от всего autosomes. Из-за неуверенности, определяющейся наследования и диагноза, четыре различных модели, которые принимают, материнская экспрессия гена использовалась, чтобы провести lod - ВЫИГРЫВАЮТ анализ. Область между D4S450 и D4S610 (2.8 см) на длинной руке хромосомы 4 была идентифицирована как сильный кандидат область для pe/E-SUSCEPTIBILITY очага. Максимальный многоточечный счет(ряд) lod в пределах этого интервала был 2.9. Анализ маркеров в области вокруг D4S450 и D4S610 методом поврежденной-родословной-члена также поддержал возможность очага восприимчивости в этой области. Однако, чтобы проверять или исключить окончательно связь к этой области, другие группы pe/E родословных будут требоваться.
TI: Review: immunobiology of preeclampsia.
Обзор: immunobiology преэклампсии.
AU: Taylor-RN
AD: Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, School of Medicine, San Francisco 94143-0556, USA.
SO: Am-J-Reprod-Immunol. 1997 Jan; 37(1): 79-86
CP: DENMARK
AB: Preeclampsia has been recognized clinically since the time of Hippocrates: however its etiology and pathophysiology remain enigmatic. This pregnancy-specific syndrome typically presents in late pregnancy as hypertension, edema, and proteinuria. Investigations over the past 15 years have revealed that preeclampsia is associated with abnormal placentation, reduced placental perfusion, endothelial cell dysfunction, and systemic vasospasm. Since it occurs more commonly in primigravidae and in women with underlying collagen-vascular diseases, an immunological component has long been suspected. Increased prevalence in high-order and molar pregnancies and those associated with increased placental mass suggests that trophoblastic volume and fetal antigen load are correlated with the syndrome. Epidemiological reports indicate that the prevalence of preeclampsia is decreased in women who received heterologous blood transfusions, practiced oral sex, or when a long period of cohabitation preceded an established pregnancy. Conversely, the use of condoms as a primary mode of contraception is associated with a higher risk of preeclampsia. These studies suggest that prior exposure to foreign or paternal antigens imparts a protection against the likelihood of developing preeclampsia. Clinical evidence of cellular and humoral immune dysfunction is associated with the syndrome. Fibrin and complement deposition and "foam" cells in atherosis lesions resemble the histopathology of renal allograft rejection. Relative T-cell, natural killer cell, and neutrophil activation have been reported in preeclampsia and circulating cytokines and antiphospholipid antibodies are more prevalent in preeclampsia than in normal pregnant women. These abnormalities are consistent with the systemic endothelial cell dysfunction that has been postulated as a pathophysiological feature of preeclampsia. While such associations do not prove causality, they suggest testable hypotheses for continued basic and clinical investigation of this major complication of human pregnancy.
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