TI: Anticardiolipin antibodies in pre-eclampsia and intrauterine growth retardation. :
anticardiolipin антитела в преэклампсии и задержке внутриутробного развития.
AU: D'Anna-R; Scilipoti-A; Leonardi-J; Scuderi-M; Jasonni-VM; Leonardi-R
AD: Institute of Gynecology, University of Messina, Italy.
SO: Clin-Exp-Obstet-Gynecol. 1997; 24(3): 135-7
LA: ENGLISH
CP: ITALY
AB: OBJECTIVE: To establish an association of anticardiolipin antibody (ACA) levels and pre-eclampsia or intrauterine growth retardation (IUGR). METHODS: Twenty-eight patients with pre-eclampsia, 28 with IUGR and 28 normotensive control group were matched for maternal age, race, weight, cigarette smoking, and parity. All had plasma anticardiolipin antibodies (GPL and MPL) detected by the modified enzyme-linked immuno-absorbent assay (ELISA) technique. RESULTS: No statistical significant difference in ACA values, both GPL and MPL, was found among the three groups studied Furthermore, none reached a value of ACA that could be considered clinically relevant (> 15). CONCLUSION: No association was found in anticardiolipin antibody levels between pre-eclamptic and IUGR versus the control group. :
ЦЕЛЬ: отрабатывать ассоциацию anticardiolipin антитела (ACA) выравнивается и преэклампсия или задержка внутриутробного развития (IUGR). МЕТОДЫ: Двадцать восемь пациентов с преэклампсией, 28 с IUGR и 28 normotensive контрольная группа были согласованы в течение материнского возраста, расы, веса, курения сигареты, и паритета. Все имел плазму anticardiolipin антитела (GPL и MPL) обнаруженный модифицированным связанным ферментом immuno - гигроскопичная проба (elisa) техника. РЕЗУЛЬТАТЫ: Никакое статистическое значительное различие в ценностях ACA, и GPL и MPL, не было найдено среди этих трех групп, изученных Кроме того, ни один не достиг ценности ACA, который мог рассматриваться клинически связанным с лечением (> 15). ЗАКЛЮЧЕНИЕ: Никакая ассоциация не была найдена в anticardiolipin уровнях антитела между пред--eclamptic и IUGR против контрольной группы.
TI: Altered mRNA expression pattern of placental epidermal growth factor receptor (EGFR) in pregnancies complicated by preeclampsia and/or intrauterine growth retardation.
: Измененная структура экспрессии мРНК плацентарного эпидермального рецептора фактора роста (EGFR) в беременностях, осложненных преэклампсией и/или задержкой внутриутробного развития.
AU: Faxen-M; Nasiell-J; Blanck-A; Nisell-H; Lunell-NO
AD: Department of Obstetrics and Gynecology, Karolinska Institute, Huddinge University Hospital, Sweden.
SO: Am-J-Perinatol. 1998 Jan; 15(1): 9-13
CP: UNITED-STATES
AB: Placental pathology in preeclampsia (PE) and intrauterine growth retardation (IUGR) is associated with alterations of the placental epidermal growth factor receptor (EGFR). It is encoded by a single gene, which gives rise to two different full-length transcripts and one putative truncated transcript in the placenta. The aim was to investigate if the placental mRNA expression pattern of EGFR differs between women with PE and/or IUGR and normal pregnancies. Tissue samples from placentas were obtained immediately after delivery. Total nucleic acids were prepared and mRNA levels of EGFR transcripts were measured by a solution hybridization technique. In the group with IUGR the placental mRNA expression of the two full-length transcripts was found to be significantly lower than in placentas from normal pregnancy, whereas the expression of the truncated transcript was higher. The groups with PE or PE with IUGR had a significantly higher mRNA expression of the truncated transcript, while there were no significant differences in the mRNA expression of the two full-length transcripts. These findings are consistent with an important role for EGFR in the regulation of placental and fetal growth.
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