ГЕМОСТАЗ
TI: [The course of pregnancy and delivery among women with thrombocytopenia] [ Курс беременности и родоразрешения среди женщин с тромбоцитопенией]
TO: Przebieg ciazy i porodu u kobiet z maloplytkowoscia.
AU: Szymanski-W; Sarap-J; Kujawa-A; Pasinska-M
AD: Katedry i Kliniki Poloznictwa i Chorob Kobiecych AM w Bydgoszczy.
SO: Ginekol-Pol. 1998 Dec; 69(12): 1003-6
CP: POLAND
AB: Between January 1987 and December 1997 in The Ludwik Rydygier Medical University in Bydgoszcz 10 pregnant woman with autoimmune or "gestational" thrombocytopenia and preeclampsia--associated thrombocytopenia were evaluated. All of the patients delivered naturally and one delivered by caesarean section for obstetric indications. Severe neonatal thrombocytopenia was observed in one of newborns.
: Между январем 1987 и декабрем 1997 в Лудвике Ридигиере Медицинский Университет в Быдгоще 10 беременных женщин с автоиммунной(автосвободной) или "гестациозной" тромбоцитопенией и преэклампсией - связанная тромбоцитопения была оценена. Весь из пациентов поставил естественно и один поставленный секцией монархиста для акушерских показаний. Тяжелая новорожденная тромбоцитопения наблюдалась(соблюдалась) у одного новорожденных.
TI: High prevalence of hemostatic abnormalities in women with a history of severe preeclampsia.
Высокая распространенность гемостатических расстройств в женщинах с историей тяжелой преэклампсии.
AU: van-Pampus-MG; Dekker-GA; Wolf-H; Huijgens-PC; Koopman-MM; von-Blomberg-BM; Buller-HR
AD: Department of Gynecology and Obstetrics, Center of Hemostasis, Thrombosis, Atherosclerosis and Inflammation Research, Academic Medical Center, Amsterdam, The Netherlands.
SO: Am-J-Obstet-Gynecol. 1999 May; 180(5): 1146-50
CP: UNITED-STATES
AB: OBJECTIVE: In patients with a history of severe preeclampsia, an increased frequency of hemostatic abnormalities has recently been suggested in small studies without control groups. Our purpose was to investigate the prevalence of such abnormalities in a large patient group with a history of severe hypertensive disorder in pregnancy, in comparison with an appropriate control group. STUDY DESIGN: A total of 345 patients with a history of severe preeclampsia were investigated at a minimum of 10 weeks post partum for the presence of activated protein C resistance, the associated factor V mutation, hyperhomocysteinemia and anticardiolipin antibodies. The control group consisted of 67 healthy women with a history of uncomplicated pregnancies only. Blood was obtained during the second half of a normal menstrual cycle, and none of the patients or control subjects used oral contraceptives. RESULTS: Of all patients, 11.3% had activated protein C resistance (control subjects 1.5%, P =.025). Only half of these patients had the factor V mutation. Hyperhomocysteinemia was present in 12.1% of all patients, in comparison with 4.5% in the control group (P =.115). Anticardiolipin antibodies were observed in 20.9% of the patients, whereas these antibodies were found in 7.5% of the control subjects (P =.016). In general, the prevalence of these abnormalities was 1.5 to 2 times higher in patients who were delivered before 28 weeks, in comparison with patients who were delivered after 28 weeks. CONCLUSIONS: Hemostatic abnormalities, associated with an increased risk of thrombosis, are present in approximately 40% of patients with a history of severe preeclampsia, which is almost 4 times higher than in control subjects. These findings might suggest a cause of preeclampsia and could have implications in subsequent pregnancies and general health.
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