Сопротивление опосредованному инсулином поглощению глюкозы и гиперинсулинемии в женщинах, страница 11

AB: OBJECTIVE: Because pregnant women with diabetes have an increased risk of preeclampsia, we tested the hypothesis that urinary excretion of thromboxane metabolites is increased in diabetic pregnancies without evidence of preeclampsia at the time of testing. STUDY DESIGN: Urinary excretion of thromboxane A2 metabolites (either 2,3-dinor-thromboxane B2 or 11-dehydro-thromboxane B2) was measured in 24 type I pregnant diabetic individuals and in 20 women with normal pregnancies between 28 and 32 weeks' gestation. RESULTS: The amount of 2,3-dinor-thromboxane B2 and 11-dehydro-thromboxane B2 in the urine of pregnant women with diabetes (1727 +/- 415 and 827 +/- 276 pg/mg creatinine) was significantly higher than in women with normal pregnancies (638 +/- 218 and 178 +/- 145 pg/mg creatinine) (p < 0.002 and p < 0.001). CONCLUSION: Our findings support a role for thromboxane in the pathogenesis of preeclampsia. Поскольку беременные женщины с диабетом имеют увеличенный риск преэклампсии, мы тестировали гипотезу, что мочевая экскреция метаболитов тромбоксана увеличена в диабетических беременностях без признака преэклампсии во время испытания. ПРОЕКТ ИЗУЧЕНИЯ: Мочевая экскреция тромбоксана A2 метаболиты (или 2,3-dinor-thromboxane B2 или 11-dehydro-thromboxane B2) была измерена в 24 типах 1 беременные диабетические индивидуумы и в 20 женщинах с нормальными беременностями между беременностью 28 и 32 недель. РЕЗУЛЬТАТЫ: количество 2,3-dinor-thromboxane B2 и 11-dehydro-thromboxane B2 в моче беременных женщин с диабетом (1727 +/-415 и 827 +/-276 PG/mg креатинин) было значительно выше чем в женщинах с нормальными беременностями (638 +/-218 и 178 +/-145 PG/mg креатинин) (p < 0.002 и p < 0.001). ЗАКЛЮЧЕНИЕ: Наши результаты поддерживают роль для тромбоксана в патогенезе преэклампсии.

TI: Hyperinsulinemia in glucose-tolerant women with preeclampsia. A controlled study.

TI: Гиперинсулинемия в толерантных глюкозой женщинах с преэклампсией. Управляемое изучение.

AU: Martinez-Abundis-E; Gonzalez-Ortiz-M; Quinones-Galvan-A; Ferrannini-E

AD: Hospital de Ginecoobstetricia, Centro Medico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico.

SO: Am-J-Hypertens. 1996 Jun; 9(6): 610-4

AB: Essential hypertension is associated with insulin resistance and hyperinsulinemia. To assess whether hyperinsulinemia is also present in hypertensive disease induced by pregnancy, we studied the plasma glucose and insulin responses to 50 g of oral glucose in 10 women with definite, severe preeclampsia but normal glucose tolerance, and compared them with the responses observed in a well-matched control group of healthy pregnant women. Fasting plasma glucose concentrations were similar in healthy and preeclamptic pregnant mothers (4.1 +/- 0.4 mmol/L v 4.5 +/- 0.4 mmol/L, respectively, P = NS). Similar plasma glucose levels were also observed after glucose ingestion (5.5 +/- 0.3 mmol/L v 6.2 +/- 0.3 mmol/L in healthy and preeclamptic women, respectively P = NS). In contrast, fasting plasma insulin concentrations in the preeclamptic women were significantly higher than in normal pregnant mothers (175 +/- 29 pmol/L v 101 +/- 11 pmol/L, P < .05). Postload plasma insulin concentrations were nearly fourfold higher in the preeclamptic group as compared with the control group (1162 +/- 70 pmol/L v 366 +/- 39 pmol/L, P < .01). We conclude that preeclampsia is associated with marked hyperinsulinemia both in the fasting state and after oral glucose ingestion, suggesting that insulin resistance may play a role in pregnancy-induced hypertension.