AB: OBJECTIVE: During normal human ontogenesis an overexpression of the c-erbB-2 encoded oncoprotein p185 (HER2/neu) occurs in the placenta and on fetal epithelial cells. It is accompanied by the increase of a 105 kD fragment (p105) in both maternal serum and cord blood. We examined whether p105 levels in maternal serum are influenced by destructions of placental tissue, fetal growth disturbances and placental circulation disorders. METHODS: We analysed p105 serum concentrations in patients with abortion (n = 25), ectopic pregnancy (n = 5), intrauterine growth retardation (n = 9), pregnancy induced hypertension (n = 24) and compared them with normal pregnancies of a corresponding gestational age. RESULTS: Patients with abortions showed normal p105 values. Intrauterine growth retardation was associated with lower p105 levels (p < 0.05) whereas patients with pure preeclampsia (p < 0.001) and HELLP syndrome (p < 0.05) had significantly higher levels. CONCLUSION: The elevation of p105 in sera of preeclamptic women could be due to an increased fetomaternal transfer of p105. : В течение нормального человеческого онтогенеза overexpression c-erbB-2 кодировал oncoprotein p185 (HER2/neu), встречается в плаценте и на эмбриональных эпителиальных ячейках. Это сопровождается увеличением из 105 kD фрагмент (p105) в и материнской сыворотке и крови пуповины(шнура). Мы исследовали, являются ли уровни p105 в материнской сыворотке под влиянием деструкций плацентарной ткани, эмбриональных нарушений роста и плацентарных нарушений кровообращения. МЕТОДЫ: Мы анализировали p105 серологические концентрации у больных с абортом (n = 25), эктопическая беременность (n = 5), задержка внутриутробного развития (n = 9), беременность вынужденная(вызванная) артериальная гипертензия (n = 24) и сравнили их с нормальными беременностями соответствующего гестациозного возраста. РЕЗУЛЬТАТЫ: Пациенты с абортами показывали нормальным ценностям p105. Задержка внутриутробного развития была связана с более низкими уровнями p105 (p < 0.05) принимая во внимание, что пациенты с чистой преэклампсией (p < 0.001) и hellp синдромом (p < 0.05) имели значительно более высокие уровни. ЗАКЛЮЧЕНИЕ: Возвышение p105 в сыворотке preeclamptic женщин могло быть вследствие увеличенная передача(перемещение) fetomaternal p105.
TI: Absence of innervation of the uteroplacental arteries in normal and abnormal human pregnancies.
: Отсутствие иннервации uteroplacental артерий в нормальных и патологических человеческих беременностях.
AU: Khong-TY; Tee-JH; Kelly-AJ
AD: Department of Pathology, Women's and Children's Hospital, North Adelaide, Australia.
SO: Gynecol-Obstet-Invest. 1997; 43(2): 89-93
CP: SWITZERLAND
AB: The spiral arteries of the human uterus are considerably remodeled structurally during pregnancy to facilitate an increase in blood flow. An immunohistochemical study was undertaken to determine whether the spiral arteries were innervated and, if so, whether they were denervated in the process of the physiologic vascular changes of normal pregnancy or, conversely, remained innervated in the absence of physiologic changes in abnormal pregnancy. Uterine tissues from nonpregnant nulliparous women, from normal early pregnancy, from normal late pregnancy, from abnormal early pregnancy (i.e. spontaneous abortions), and from abnormal late pregnancy (i.e. preeclampsia and intrauterine growth retardation) were subjected to immunohistochemistry using a panel of neuron-associated antibodies (neurofilament, neuron-specific enolase, S100 protein, protein gene product 9.5). All sections of the nonpregnant uterus showed an abundance of nerves deep in the myometrium, some of which were associated with radial and arcuate arteries. Very few nerves were demonstrated at the endomyometrial junction and no nerves were seen accompanying the intramyometrial spiral arteries. In both normal and abnormal pregnancy, nerves were not detected in the decidua or accompanying intradecidual spiral arteries, whether they were physiologically altered or not. Nerves were seen in the myometrium in 7 of 10 normal and in 1 of the 8 third-trimester abnormal placental beds, but none were seen accompanying intramyometrial spiral arteries, whether showing physiological changes or not. The lack of innervation of the spiral arteries in the nonpregnant state as well as in normal and abnormal pregnancy suggests that nonneurogenic mechanisms control blood flow at the spiral-arterial level.
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