Сопротивление опосредованному инсулином поглощению глюкозы и гиперинсулинемии в женщинах

TI: Resistance to insulin-mediated glucose uptake and hyperinsulinemia in women who had preeclampsia during pregnancy.

TI: Сопротивление опосредованному инсулином поглощению глюкозы и гиперинсулинемии в женщинах который(кто) имело преэклампсию в течение беременности.

AU: Fuh-MM; Yin-CS; Pei-D; Sheu-WH; Jeng-CY; Chen-YI; Reaven-GM

AD: Division of Endocrinology and Metabolism, Tri-Services General Hospital, Taipei, Taiwan, Republic of China.

SO: Am-J-Hypertens. 1995 Jul; 8(7): 768-71

AB: Plasma glucose and insulin responses to a 75-g oral glucose load, and the steady-state plasma insulin (SSPI) and glucose (SSPG) concentrations after an infusion of somatostatin, insulin, and glucose, were determined 2 months after delivery in 26 women; 13 who had a normal pregnancy and 13 who developed preeclampsia. The plasma glucose response to oral glucose was not different in the two groups, but the plasma insulin response was significantly greater (P < .02) in those who had been preeclamptic. Although the mean (+/- SE) SSPI concentrations during the infusion study were similar in the two groups (51 +/- 2 v 56 +/- 2 microU/mL), the SSPG concentrations were significantly higher (P < .02) in those who developed preeclampsia (160 +/- 17 v 119 +/- 17 mg/dL). Thus, when studied 2 months after delivery, women who developed preeclampsia were relatively insulin resistant and hyperinsulinemic when compared to those who had an uncomplicated pregnancy.

: Плазменная глюкоза и реакции инсулина на устный груз глюкозы на 75 г, и установившийся плазменный инсулин (SSPI) и глюкозу (SSPG) концентрации после вливания соматостатина, инсулина, и глюкозы, были определены 2 месяцами после родоразрешения в 26 женщинах; 13 который(кто) имел нормальную беременность и 13 которых(кого) развитых преэклампсий. Плазменная реакция глюкозы на устную глюкозу не была различна в этих двух группах, но плазменная реакция инсулина была значительно большая (P < .02) в те которая(кто), был preeclamptic. Хотя средний (+/-se) SSPI концентрации в течение изучения вливания были подобен(сходен) в этих двух группах (51 +/-2 v 56 +/-2 microU/mL), SSPG концентрации были значительно выше (P < .02) в той которой(ком) развитой преэклампсии (160 +/-17 v 119 +/-17 mg/dl). Таким образом, когда изучено 2 месяцами после родоразрешения, женщины которая(кто) развитая преэклампсия была относительно инсулин, устойчивый и hyperinsulinemic, когда по сравнению с те который(кто) имел несложную беременность.

TI: Impact of increasing carbohydrate intolerance on maternal-fetal outcomes in 3637 women without gestational diabetes. The Toronto Tri-Hospital Gestational Diabetes Project.

TI: Воздействие увеличивающего отсутствия толерантности углевода на материнских-эмбриональных результатах в 3637 женщинах без гестациозного диабета. Торонто tri - Стационарный Гестациозный Проект Диабета.

AU: Sermer-M; Naylor-CD; Gare-DJ; Kenshole-AB; Ritchie-JW; Farine-D; Cohen-HR; McArthur-K; Holzapfel-S; Biringer-A; et-al

AD: Department of Obstetrics and Gynecology, University of Toronto, Ontario, Canada.

SO: Am-J-Obstet-Gynecol. 1995 Jul; 173(1): 146-56

AB: OBJECTIVE: Our purpose was to assess maternal-fetal outcomes in patients with increasing carbohydrate intolerance not meeting the current criteria for the diagnosis of gestational diabetes. STUDY DESIGN: We conducted a prospective analytic cohort study in which nondiabetic women aged > or = 24 years, receiving prenatal care in three Toronto teaching hospitals, were eligible for enrollment. A glucose challenge test and an oral glucose tolerance test were administered at 26 and 28 weeks' gestation, respectively; risk factors for unfavorable maternal-fetal outcomes were recorded. Caregivers and patients were blinded to glucose values except when test results met the current criteria for gestational diabetes. RESULTS: Of 4274 patients screened, 3836 (90%) continued to the diagnostic oral glucose tolerance test. The study cohort was formed by the 3637 (95%) patients without gestational diabetes, carrying singleton fetuses. Increasing carbohydrate intolerance in women without overt gestational diabetes was associated with a significantly increased incidence of cesarean sections, preeclampsia, macrosomia, and need for phototherapy, as well as an increased length of maternal and neonatal hospital stay. Multivariate analysis showed that increasing carbohydrate intolerance is an independent predictor for various unfavorable outcomes. CONCLUSION: Increasing maternal carbohydrate intolerance in pregnant women without gestational diabetes is associated with a graded increase in adverse maternal-fetal outcomes.