BCL10 gene mutations rarely occur in lymphoid malignancies

Lymphoma, B-Cell--Metabolism--ME; *Trans-Activators--Metabolism--ME; Antigens, CD-Genetics--GE; B-Lymphocytes--Pathology--PA; B-Lymphocytes--Physiology--PH; Cell Aging-Physiology--PH; Cell Differentiation; Cell Line; Lymphoma, B-Cell--Pathology--PA;

Mice; Mutation; Receptors, Tumor Necrosis Factor--Genetics--GE; Reference Values;

Spleen--Cytology--CY; Spleen--Metabolism--ME; Up-Regulation (Physiology)

CAS Registry No.: 0   (lymphotoxin beta-specific receptor); 0   (tumor necrosis

factor receptor 55); 0   (Antigens, CD); 0   (Bob1 protein); 0   (Receptors, Tumor

Necrosis Factor); 0   (Trans-Activators)

36  Complete Record

20127414

Infrequent BCL10 mutations in B-cell non-Hodgkin's lymphomas.

Takahashi H; Hosokawa Y; Suzuki R; Morishima Y; Nakamura S; Seto M

Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya.

Japanese journal of cancer research  (JAPAN)  Dec 1999  90 (12) p1316-20  ISSN:

0910-5050

Language: ENGLISH

Document Type:   JOURNAL ARTICLE      

Journal Announcement: 0005

Subfile: INDEX MEDICUS

The BCL10 gene was recently isolated from the breakpoint region of t(1;14)(p22;q32)

in mucosa-associated lymphoid tissue (MALT) lymphomas.  Somatic mutations of BCL10

were found in not only t(1;14)-bearing MALT lymphomas, but also a wide range of other

tumors.  To clarify the actual frequency and spectrum of BCL10 mutations in primary Bcell non-Hodgkin's lymphomas (NHL), we examined a total of 139 NHL cases comprising

25 with MALT lymphomas, 54 with follicular B-cell lymphomas (FCL), and 60 with

diffuse large B-cell lymphomas (DLBL).  Polymerase chain reaction single-strand

conformation polymorphism (PCR-SSCP) and sequencing analyses led to the

identification of four nucleotide changes in FCL and one in DLBL.  In contrast, no

BCL10 mutations were found in our series of MALT lymphomas.  While screening for

mutations, we also found three polymorphic sequence variants at codons 5 and 213 and

in intron 1 of the BCL10 gene.  Our results strongly suggest that somatic mutations

of BCL10, if they occur at all, are rare in B-cell NHLs and do not commonly

contribute to their molecular pathogenesis.

Tags: Human; Support, Non-U.S. Gov't

Descriptors: *Lymphoma, B-Cell--Genetics--GE; *Mutation; *Neoplasm Proteins-Genetics--GE; Blotting, Southern; DNA, Neoplasm--Analysis--AN; DNA, Neoplasm-Genetics--GE; Lymphoma, Follicular--Genetics--GE; Lymphoma, Large-Cell, Diffuse-Genetics--GE; Lymphoma, Mucosa-Associated Lymphoid Tissue--Genetics--GE; Polymerase

Chain Reaction; Polymorphism, Single-Stranded Conformational

CAS Registry No.: 0   (Bcl10 protein); 0   (DNA, Neoplasm); 0   (Neoplasm Proteins)

45  Complete Record

20105774

Identification of heterologous translocation partner genes fused to the BCL6 gene

in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples.

Yoshida S; Kaneita Y; Aoki Y; Seto M; Mori S; Moriyama M

Department of Pathology, Institute of Medical Science, The University