Prognostic factors of oesophageal squamous cell carcinoma from the perspective of molecular biology

1  Complete Record

99303478

Prognostic factors of oesophageal squamous cell carcinoma from the perspective of

molecular biology.

Shimada Y; Imamura M; Watanabe G; Uchida S; Harada H; Makino T; Kano M

Department of Surgery and Surgical Basic Science, Graduate School of Medicine,

Kyoto University, Japan.

British journal of cancer  (SCOTLAND)  Jun 1999  80 (8) p1281-8  ISSN: 0007-0920

Language: ENGLISH

Document Type:   JOURNAL ARTICLE      

Journal Announcement: 9909

Subfile: INDEX MEDICUS

Recent developments in molecular biology have revealed that several oncogenes,

suppressor genes and adhesion molecules are involved in the development of

oesophageal cancer; however, the role of these genes is still unknown.  To evaluate

which molecular biological factors are related to patients' prognosis and recurrence,

we checked p53, p16, p21/Waf1, cyclin D1, Ki-67, epidermal growth factor receptor

(EGFR), vascular endothelial growth factor (VEGF), Mdm2, Bcl2, E-cadherin and MRP1/

CD9 by means of immunohistochemical analysis in 116 cases of oesophageal cancer (R0). 

We also checked the regrowth capability of the primary cultures of the resected

tumours and the effect of post-operative treatment.  Although univariate analysis

revealed that pN (pTNM), pT (pTNM), sex, cyclin D1, Ki-67, VEGF, E-cadherin and cell

regrowth capability were prognostic factors, multivariate analysis revealed that pN

(risk ratio (RR) 3.17), sex (RR 8.13), cell regrowth capability (RR 3.03) and Ecadherin (RR 0.30) were prognostic factors.  Interestingly, step-wise analysis

revealed that the following five factors were prognostic factors: pN (RR 5.74), sex

(RR 3.14), cyclin D1 (RR 2.29), E-cadherin (RR 0.26) and cell regrowth capability (RR

1.94).  Logistic regression analysis revealed that the risk factors of haematogenous

recurrence were pN (odds ratio (OR) 8.97), cyclin D1 (OR 4.52) and EGFR (OR 0.18). 

On the other hand, the risk factor of lymph node recurrence was pN (OR 5.16).  With

regard to the effect of postoperative treatment, post-operative radiotherapy was a

favourable risk factor (RR 0.43) and reduced the haematogenous recurrence (OR 0.18). 

Our data indicate that combination analysis using pN, sex, cyclin D1, E-cadherin,

EGFR and cell regrowth capability may be useful for the prediction of patient

survival and recurrence.

Tags: Female; Human; Male; Support, Non-U.S. Gov't

Descriptors: *Carcinoma, Squamous Cell--Pathology--PA; *Esophageal Neoplasms-Pathology--PA; *Tumor Markers, Biological--Analysis--AN; Aged; Cadherins--Analysis-AN; Carcinoma, Squamous Cell--Genetics--GE; Carcinoma, Squamous Cell--Radiotherapy-RT; Cyclin D1--Analysis--AN; Esophageal Neoplasms--Genetics--GE; Esophageal Neoplasms-Radiotherapy--RT; Immunohistochemistry; Middle Age; Neoplasm Recurrence, Local;

Prognosis; Receptor, Epidermal Growth Factor--Analysis--AN; Risk Factors; Survival

Analysis; Treatment Outcome

CAS Registry No.: 0   (Cadherins); 0   (Tumor Markers, Biological); 136601-57-5  

(Cyclin D1)

Enzyme No.: EC 2.7.11.-   (Receptor, Epidermal Growth Factor)

13  Complete Record

99334886

Bcl10 is not a target for frequent mutation in human carcinomas.

Lambers AR; Gumbs C; Ali S; Marks JR; Iglehart JD; Berchuck A; Futreal PA

Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.

British journal of cancer  (SCOTLAND)  Jul 1999  80 (10) p1575-6  ISSN: